Preparation of Combination Tablet Containing Lisinopril (10mg)/Hydrochlorothiazide (12.5mg): Characterization and Stability studies

In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, disintegration time, dissolution and stability. A high-performanceliquid-chromatographic method (HPLC) was used to assay Hctz and Lis in the prepared tablets.Amongst different formulations, WG14 was found to be the best for product development basedon both physicochemical and stability results. Pharmaceutical characteristics of the tablets werecompared with the Innovator tablet 1A-Pharma (Germany).